Full Frame Glass
FESony E278ZNikon Z141RFCanon RF96

Sony E-mount lenses

  • 7Artisans
  • Laowa
  • Samyang (Rokinon)
  • Sigma
  • Sirui
  • Sony
  • Tamron
  • Viltrox
  • Voigtländer
  • Zeiss
  • Ultra-Wide
  • Wide
  • Standard
  • Short Telephoto
  • Telephoto
  • Super-Telephoto
  • Macro

Nikon Z-mount lenses

  • 7Artisans
  • Laowa
  • Nikon
  • Samyang (Rokinon)
  • Sirui
  • Tamron
  • Viltrox
  • Voigtländer
  • Ultra-Wide
  • Wide
  • Standard
  • Short Telephoto
  • Telephoto
  • Super-Telephoto
  • Macro

Canon RF-mount lenses

  • 7Artisans
  • Canon
  • Laowa
  • Samyang (Rokinon)
  • Viltrox
  • Voigtländer
  • Ultra-Wide
  • Wide
  • Standard
  • Short Telephoto
  • Telephoto
  • Super-Telephoto
  • Macro

Full Frame Glass

Native full-frame mirrorless lenses only: no crop lenses, no adapted glass. Specifications, MTF charts and product images come from manufacturer publications and are credited on each page.

  • About & methodology
  • Affiliate disclosure
  • Privacy
  • Terms
  • Contact
  • © Full Frame Glass
Register/Compare

Canon RF 100-400mm F5.6-8 IS USM vs Canon RF 75-300mm F4-5.6

Key differences

  • —The RF 75-300mm F4-5.6 is 128g lighter (507g vs 635g).
  • —The RF 75-300mm F4-5.6 is faster: f/4 vs f/5.6 (≈1.0 stops more light).
  • —At launch the RF 75-300mm F4-5.6 cost $430 less ($219 vs $649).
  • —For close-ups the RF 100-400mm F5.6-8 IS USM reaches 0.41× vs 0.25×.
Canon
RF 100-400mm F5.6-8 IS USM
Canon RF 100-400mm F5.6-8 IS USM
Canon
RF 75-300mm F4-5.6
Canon RF 75-300mm F4-5.6
Mount
Canon RF
Canon RF
Focal length
100–400mm
75–300mm
Max aperture
F5.6–8
F4–5.6◆
Weight
635g
507g◆
Dimensions ⌀ × L
79.5 × 164.7mm
71.2 × 146.1mm
Volume
818 cm³
582 cm³◆
Density
0.78 g/cm³
0.87 g/cm³
Filter thread
⌀67mm
⌀58mm
Min focus
0.88m◆
1.50m
Max magnification
0.41×◆
0.25×
Elements / groups
12 / 9
13 / 9
Aperture blades
9◆
7
Focus drive
Nano USM
DC Motor
Stabilisation
Yes
—
Weather sealed
—
—
Aperture ring
—
—
Released
2021
2025
MSRP (USD)
$649
$219◆
Sharpness
7.6◆
6.0
Bokeh Rendering
6.4
6.5◆
Autofocus Speed
8.0◆
5.6
Flare Resistance
7.8◆
6.3
Build / Sealing
6.8◆
5.8
Value / Size
9.3◆
7.8
SHARPBOKEHAFFLAREBUILDVALUE

Performance overlay

  • RF 100-400mm F5.6-8 IS USM
  • RF 75-300mm F4-5.6

◆ marks the best value in a row. Scores are 0–10 editorial ratings.